By Howard Rogers and Roy G. Spector (Auth.)
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Extra resources for An Introduction to Mechanisms in Pharmacology and Therapeutics
Clearly much work will be required before receptor material can be isolated as a pure chemical substance. Nevertheless progress has been made towards a better understanding of their properties and already it is possible to draw together various observations in the form of a model for specific receptors. Some of these will be further discussed in later chapters. REFERENCES Arunlakshana O. and Schild Η. Ο. (1959) Some quantitative uses of drug antagonists Brit. J. Pharmac. 14, 48 - 58. Burgen A. S.
J. (editors) 1969 Fundamental concepts in drug receptor interactions Academic Press. , Fleisch J. H. and Mittag T. W. (1969) Approaches to the molecular nature of pharmacological receptors Pharmac. Rev. 2 1 , 131-81 Kasai M. P. (1971) In vitro excitation of purified membrane fragments by cholinergic agonists I Pharmacological properties of the excitable membrane fragments/. Memb. Biol. 6, 1 - 23. Mackay D. ( 1966) The mathematics of drug-receptor interactions /. Pharm. Pharmac, 18, 201 - 222. , Molinoff P.
Thus not only would the surfaces of the membrane contain both protein and lipid elements, but the hydrophobic core would consist of intercalations of protein and lipid through which penetrate polar channels. The lipid layer, which has been thought to consist of an organised crystalline bimolecular leaflet of lipid is now considered by some workers to be much less structured than this. It thus appears that the lipid molecules are not all closely packed side-to-side and oriented tail to tail, but at least some of the hydrocarbon portions of the molecules are in a state of disorder similar to a liquid lipid.